'Disease X': UK scientists begin developing vaccines against new pandemic (2024)

UK scientists have begun developing vaccines as an insurance against a new pandemic caused by an unknown "Disease X".

The work is being carried out at the government's high-security Porton Down laboratory complex in Wiltshire by a team of more than 200 scientists.

They have drawn up a threat list of animal viruses that are capable of infecting humans and could in future spread rapidly around the world.

Which of them will break through and trigger the next pandemic is unknown, which is why it's referred to only as "Disease X".

Sky News was escorted around the site, which is run by the UK Health Security Agency, to see the work being done in high-containment labs.

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'Disease X': UK scientists begin developing vaccines against new pandemic (1) 0:26

Professor Dame Jenny Harries, the head of the UK Health Security Agency (UKHSA), told Sky News: "What we're trying to do here is ensure that we prepare so that if we have a new Disease X, a new pathogen, we have done as much of that work in advance as possible.

"Hopefully we can prevent it [a pandemic]. But if we can't and we have to respond, then we have already started developing vaccines and therapeutics to crack it."

The Vaccine Development and Evaluation Centre at Porton Down has been expanded to take on the work.

Originally, it was focused on COVID and testing the effectiveness of vaccines against new variants.

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But scientists at the centre are now involved in monitoring several high-risk pathogens, including bird flu, monkeypox and hantavirus, a disease spread by rodents.

'Disease X': UK scientists begin developing vaccines against new pandemic (2)

One early success is the world's first vaccine against Crimean-Congo haemorrhagic fever, a disease that's spread by ticks and has a fatality rate of 30%.

Early-stage clinical trials have just started, with 24 volunteers expected to test the jab.

The disease is becoming more common in Europe as global temperatures rise and some travellers have returned to the UK with the infection.

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'Disease X': UK scientists begin developing vaccines against new pandemic (3)

Prof Harries said climate change and population shifts are making another pandemic more likely.

"What we're seeing is a rising risk globally," she said.

"Some of that is because of things like urbanisation where you may get virus jumping into humans [living close-by], as we've seen with bird flu.

"And some of it is because of climate change where you get things like ticks and mosquitoes moving to where it was previously cold and is now becoming increasingly warm.

"So this is a growing risk agenda. But it's one we can use our science actively to prevent human impact."

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Bird flu is currently thought to be the most likely pandemic threat.

The Royal Society for the Protection of Birds says at least 30,000 seabirds have died around the UK this summer as a more virulent strain of the H5N1 virus has swept around the world.

There is also evidence of limited spread in some mammals.

'Disease X': UK scientists begin developing vaccines against new pandemic (4)

And four people working on poultry farms in the UK have also tested positive, but were only mildly affected.

The UKHSA has started monitoring people in close contact with birds in case it can spread without causing symptoms.

The agency is part of a global effort to develop a vaccine within 100 days of a new pathogen being recognised as having pandemic potential.

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"Historically, that would be unheard of," said Prof Harries.

"It would normally take five or 10 years. For COVID it was around 360 days.

"So this is a really high ambition. But for some viruses, it is definitely possible."

'Disease X': UK scientists begin developing vaccines against new pandemic (2024)

FAQs

'Disease X': UK scientists begin developing vaccines against new pandemic? ›

UK scientists have begun developing vaccines as an insurance against a new pandemic caused by an unknown "Disease X". The work is being carried out at the government's high-security Porton Down laboratory complex in Wiltshire by a team of more than 200 scientists.

What is the Disease X? ›

With Disease X, we're preparing for an unknown unknown. Disease X is a placeholder concept that refers to a pandemic pathogen that has not yet been characterized. Its purpose is to encourage proactive thinking about pathogens that could cause a pandemic.

What is the next COVID X? ›

Scientists believe the next Disease X is highly likely to be caused by a new virus that will emerge from one of around 25 families of viruses that have already shown their capability to cause disease in people.

How did scientists come up with the COVID vaccine? ›

These vaccines were developed with NIH support and research on a protein found on SARS-CoV-2, the virus that causes COVID-19. Clinical trials for the COVID-19 vaccines in people were established in what seemed like record time.

Did the COVID vaccine help the pandemic? ›

Since their introduction in December 2020, COVID-19 vaccines have reduced deaths due to the pandemic by at least 57%, saving more than 1.4 million lives in the WHO European Region. Most of those saved were aged 60 or older, the group at highest risk of severe illness and death from the SARS-CoV-2 virus.

What are diseases that start with X? ›

Xa–Xk
  • Xanthic urolithiasis.
  • Xanthine oxydase deficiency.
  • Xanthinuria.
  • Xanthomatosis cerebrotendinous.
  • Xerocytosis, hereditary.
  • Xeroderma.
  • Xeroderma pigmentosum. Xeroderma pigmentosum, type 1. Xeroderma pigmentosum, type 2. Xeroderma pigmentosum, type 3. Xeroderma pigmentosum, type 5. ...
  • Xeroderma talipes enamel defects.

What is the X syndrome? ›

Fragile X syndrome is inherited in a way that is known as 'X-linked', as the changed gene is on the X chromosome. This means that men with Fragile X syndrome are often more severely affected than women. This is because men only have one X chromosome, whereas women have two X chromosomes, only one of which is changed.

Who was the black doctor who invented the COVID vaccine? ›

Kizzmekia Corbett, an African American Woman, is Praised as Key Scientist Behind COVID-19 Vaccine.

How long does it take to make vaccines? ›

Typical Timeline. A typical vaccine development timeline takes 5 to 10 years, and sometimes longer, to assess whether the vaccine is safe and efficacious in clinical trials, complete the regulatory approval processes, and manufacture sufficient quantity of vaccine doses for widespread distribution.

What is the fastest vaccine developed? ›

For Maurice Hilleman, the invention of the mumps vaccine combined good science and good parenting. Until COVID-19 vaccines, it would be the fastest vaccine development in history.

Does the COVID vaccine wear off? ›

The Moderna, Pfizer-BioNTech, and Novavax vaccines protect against many known variants of COVID-19. The Moderna and Pfizer-BioNTech vaccines offer immunity against COVID-19 for up to six months. To increase protection, getting an updated COVID-19 vaccine is now recommended for everyone six months and older.

How long is the COVID vaccine good for? ›

How long does the COVID vaccine last? Studies suggest COVID vaccines are most effective in the first few months following your shot. That's why when health experts recommend boosters or updated doses, they're usually given three to four months after your last COVID shot.

How effective is the COVID vaccine in 2024? ›

The newest vaccines are about 40 to 50% effective, which is not perfect. But they help a great deal in protecting against hospitalization and death.

What is the disease syndrome X? ›

Cardiac syndrome X (CSX) is characterized by typical or atypical anginal chest pain with no evidence of significant coronary vascular abnormalities visualized on angiogram. It is viewed as a type of ischemic heart disease with occurrence most prevalent in perimenopausal and postmenopausal females.

What is the disease factor X? ›

Disease Overview

Factor X deficiency is a rare genetic blood disorder that causes the normal clotting process (coagulation) to take longer than normal. This causes people to bleed for a longer amount of time spontaneously or after trauma/surgery. Factor X is a clotting protein (also called a clotting factor).

What is X virus's real name? ›

X-Virus by Godzilla2199. My real name is Cody, and since the very beginning, I've always been an unwanted kid. I never knew who my father was, and my mother was a criminal, too busy with her scheming to worry about me. She left me for days, sometimes weeks, so I soon got used to being alone, I've never had friends.

What is the X disease in children? ›

The genetic disorder Fragile X syndrome, which results from mutations in a gene on the X chromosome, is the most commonly inherited form of developmental and intellectual disability.

References

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